Poulin lab

 Understanding the function and malfunction of dopamine circuits


Pereira Luppi M*,  Azcorra M*, Caronia-Brown G*, Poulin JF, Gaertner Z, Gatica S, Moreno-Ramos OA, Nouri N, Dubois M, Ma YC, Ramakrishnan C, Fenno L, Kim YS, Deisseroth K, Cicchetti F, Dombeck DA, Awatramani RB (2021) Sox6 expression distinguishes dorsally and ventrally biased dopamine neurons in the substantia nigra with distinctive properties and embryonic origins.  Cell Reports, 37:109975. 

Kouwenhoven WM, Fortin G, Penttinen AM, Florence C, Delignat-Lavaud B, Bourque MJ, Trimbuch T, Luppi MP, Salvail-Lacoste A, Legault P, Poulin JF, Rosenmund C, Awatramani R, Trudeau LÉ (2020) VGluT2 expression in dopamine neurons contributes to postlesional striatal reinnervation.  J Neurosci, 40:8262-8275.

Poulin JF*, Pereira Luppi MP*, Hofer C, Caronia G, Hsu PK, Chan CS, Awatramani RB (2020). PRISM: A progenitor-restricted intersectional fate mapping approach redefines forebrain lineages.  Dev Cell, 53: 740-753.

Poulin JF, Gaertner Z, Moreno-Ramos OA, Awatramani RB (2020) Classification of midbrain dopamine neurons using single-cell gene expression profiling approaches. Trends Neurosci, 43:155-159. 

Chuhma N, Mingote S, Yetnikoff L, Kalmbach A, Ma T, Ztaou S, Sienna AC, Tepler S, Poulin JF, Ansorge M, Awatramani R, Kang UJ, Rayport S (2018). Dopamine neuron glutamate cotransmission evokes a delayed excitation in lateral dorsal striatal cholinergic interneurons.  eLife, 7:e39786. 

Poulin JF, Caronia G, Hofer C, Cui Q, Helm B, Ramakrishnan C, Chan CS, Dombeck DA, Deisseroth K, Awatramani RB (2018). Mapping projections of molecularly defined dopamine neuron subtypes using intersectional genetic approaches.  Nat Neurosci, 21:1260–71.

Cui Q, Pitt JE, Pamukcu A, Poulin JF, Mabrouk OS, Fiske MP, Fan IS, Augustine EC, Kelver D, Young KA, Kennedy RT, Awatramani RB, and Chan CS (2016).  Blunted mGluR activation disinhibits striatopallidal transmission in parkinsonian mice.  Cell Reports, 17:2431-44. 

Poulin JF, Tasic B, Hjerling-Leffler J, Trimarchi JM, Awatramani RB (2016)  Disentangling neuronal diversity using single-cell transcriptomics.  Nat Neurosci, 19:1131-41.
Anderegg A, Poulin JF, Awatramani RB (2015)  Molecular heterogeneity of midbrain dopaminergic neurons - Moving toward single cell resolution. FEBS letter, 589: 3714-26. 

Nouri N, Patel MJ, Joksimovic M, Poulin JF, Anderegg A, Taketo MM, Ma YC,  Awatramani RB (2015) Excessive Wnt/beta-catenin signaling promotes midbrain floor plate neurogenesis, but results in vacillating dopamine progenitors.  Mol Cell Neurosci, 68:131-142

Poulin JF, Zou J, Drouin-Ouellet J, Kwang-Youn KA, Cicchetti F, Awatramani RB (2014) Defining midbrain dopaminergic neuron diversity by single-cell gene profiling. Cell Reports, 9: 930-943. 

PhD publications: Link to  Pubmed

JAN 2022